Illumina Annotation Engine
Illumina Annotation Engine (IAE), also known as Nirvana, annotates variants. This action populates the following INFO fields in the VCF file. For more information, visit https://github.com/Illumina/Nirvana/wiki.
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Column |
Description |
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CSQT |
Contains the following values:
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CSQR |
Contains the following values:
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AF1000G |
The allele frequency from all populations of 1000 genomes data. |
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AA |
The inferred allele ancestral when it is from the chimpanzee or human lineage. |
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GMAF |
The global minor allele frequency. |
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cosmic |
The numeric identifier for the variant in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. |
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clinvar |
Clinical significance. |
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EVS |
The allele frequency, coverage, and sample count from the Exome Variant Server (EVS). |
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RefMinor |
The position where a reference base is a minor allele and annotated as a variant. |
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phyloP |
The phyloP conservation score. |