Published Fusions

File name: {SampleID}_PublishedFusions.csv

Contains a list of published fusions from the Mitelman Reference Database (“Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (2016). Mitelman F and Johansson B and Mertens F (Eds.) http://cgap.nci.nih.gov/Chromosomes/Mitelman”) that are targeted by the TruSight Tumor 170 v1.0 panel.

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When Observed=True, the fusion was called either with high or low confidence in the sample.

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When Observed=False the fusion was not detected in the sample.

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The Published Fusion report shows Mitelman fusions that have at least one gene targeted by the TruSight Tumor 170 v1.0 panel in the gene pair.

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The gene fusion column does not indicate the directionality of the fusion. For any fusion of interest, search for gene1/gene2 and gene2/gene1.

For each fusion, the following information is captured:

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Mitelman ID(s) - It is possible for a fusion to have multiple Mitelman IDs because they can have various clinical associations or interpretations

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Breakpoint 1: Gene A breakpoint from the {Sample_ID}_Fusions.csv

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Breakpoint 2: Gene B breakpoint from the {Sample_ID}_Fusions.csv

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Fusion supporting reads: Alt Split + Alt Pair values from the {Sample_ID}_Fusions.csv

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Gene 1 Reference Reads: Ref A Split + Ref A Pair values from the {Sample_ID}_Fusions.csv

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Gene 2 Reference Reads: Ref B Split + Ref B Pair values from the {Sample_ID}_Fusions.csv

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Score: Score value from the {Sample_ID}_Fusions.csv

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Filter: Pass if Keep Fusion=True else Filter = Filter column values from the {Sample_ID}_Fusions.csv

The fusions are sorted by Gene 1, then by Gene 2, then by Breakpoint 1, and then by Breakpoint 2.

For Research Use Only. Not for use in diagnostic procedures.