X-Linked Dominant Transmission Workflow
| • | A variant is on the X chromosome |
| • | The variant is heterozygous (0/1) in an affected female subject |
| • | The variant is hemizygous (1) in an affected male subject |
| • | The variant is not present (0/0 or 0) in an unaffected subject |
Typical X-Linked Dominant Transmission Logic
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Unaffected -
Affected -
Variant
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X-Linked Dominant Transmission Workflow |
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Proband |
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All variants on X |
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All heterozygous (0/1) variants in a female subject or all hemizygous (1) variants in a male subject |
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All variants that are heterozygous (0/1) or hemizygous (1) in affected subjects |
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All variants that are not present in unaffected subjects |
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All variants, if a female subject has two unaffected parents or a male subject has an unaffected mother |
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Filtering results: Deleterious variants |
Include