Illumina encourages customers to apply Illumina-tested operating system security patches on a regular basis. Illumina tests critical operating system security patches to ensure compatibility with Illumina systems running the most recent version of instrument software.
Installing Windows and Linux Operating System updates
To install and configure your Windows or Linux Operating System patches, refer to the following sections for downloadable instructions and patch files for your Illumina instrument or DRAGEN server.
Illumina Windows-based Instruments
iScan, iScanDx, iSeq 100, MiniSeq, MiSeq, MiSeqDx, NextSeq 500/550, NextSeq 550Dx, NovaSeq 6000, NovaSeq 6000Dx
Important Notes
- Windows automatic operating system security updates are disabled by default on your Illumina system. If you enable automatic system updates, it is possible that you may install untested updates that could impact system integrity.
- Installing the OS patches from the latest published PDF is sufficient to keep your instrument secure. Most patches in the PDF are cumulative, meaning the latest version includes all updates from previous patches. Any non-cumulative patches will be listed in future PDF releases, but you do not need to reinstall them if they are already installed. Refer to the installation guide for instructions on how to check the current patches installed on your instrument.
Instructions
- Download the following installation guide to install OS security patches on your Illumina Windows-based instrument.
- Find your instrument in the following table and download the latest patch file. This file includes download links for the Microsoft patches from the Microsoft Update Catalog website.
- Follow the instructions in the installation guide to install the patches.
Illumina DRAGEN Server v3, Illumina DRAGEN Server v4, Illumina DRAGEN Server for NovaSeq 6000Dx, and Illumina DRAGEN Server for NextSeq 550Dx
Important Notes
- Always make sure to download and use the latest installation guide to install the OS security patches on your Illumina DRAGEN Server.
- CentOS 7 is no longer supported– Earlier versions of Illumina DRAGEN Server v3 and v4 were shipped with CentOS 7. Refer to the installation guide to check your operating system and Illumina DRAGEN Server version (v3 or v4), if needed.
If your DRAGEN server is running CentOS 7, you must upgrade to Oracle 8 to ensure your server is secure and receives the latest OS security patches. Use the following links for your server for additional information and instructions to install Oracle 8.
- Illumina DRAGEN Server v3 – CentOS 7
- Illumina DRAGEN Server v4 – CentOS 7
Instructions
- Download the latest installation guide to install Oracle Linux security patches on your Illumina DRAGEN Server.
- Select your DRAGEN server from the list below and download the patch files specific for your server and OS image version. The instruction guide provides instructions to identify which OS image version is installed on your DRAGEN server.
- Patchset—Compressed file containing the latest OS security patches tested by Illumina.
- Install Script—Shell script that installs the patches from the patchset file and creates an installation log file. Refer to the installation guide for additional details.
- Follow the instructions in the installation guide to install the patches.
Illumina DRAGEN Server Patch Files
Illumina DRAGEN Server v3
| OS Image |
Install Script |
Patchset |
Published on |
Next Scheduled Release |
|---|
| 36.2.C02.202209201241 |
installpatchset-v3.sh
SHA-256 Checksum a88ca3933da0c7fa8d3670b962141c97479b43816c02cec75d8d14ff0632a516
|
36.2.C02.202209201241-20241018.tar.gz
SHA-256 Checksum a279de00ff64e4c0d23bd2b8d89005d53383e259208ebe8915686c1d0f4d2ae5
|
Q4 2024 |
Q2 2025 |
Illumina DRAGEN Server v4
| OS Image |
Install Script |
Patchset |
Published on |
Next Scheduled Release |
|---|
| 40.0.C11.20221017 |
installpatchset-v4.sh
SHA-256 Checksum f722862b8ca5488064fbc5d7118303e94b46d4dae593991e12db42db3b2ca658
|
40.0.C11.20221017-20241016.tar.gz
SHA-256 Checksum bd6ccf7073fcf1a092fd40ab5fc6329df4ad0e1642f2ad710677d6c39b50a6b4
|
Q4 2024 |
Q2 2025 |
| 40.0.C12.20231128 |
installpatchset-v4.sh
SHA-256 Checksum f722862b8ca5488064fbc5d7118303e94b46d4dae593991e12db42db3b2ca658
|
40.0.C12.20231128-20241016.tar.gz
SHA-256 Checksum 9bc3aba72feddab78ee1533569aabd326e5786cbb20194f25ea24cf666ecf1d6
|
Q4 2024 |
Q2 2025 |
Illumina DRAGEN Server for NextSeq 550Dx
| OS Image |
Install Script |
Patchset |
Published on |
Next Scheduled Release |
|---|
| 40.0.C12.20231128 |
N/A |
N/A |
N/A |
Coming Soon |
Illumina DRAGEN Server for NovaSeq 6000Dx
NextSeq 1000/2000
Important Notes
- Always make sure to download and use the latest installation guide for installing the TuxCare CentOS 7 security patches on your NextSeq 1000/2000 instrument.
- The patch files below are specific to the OS image version installed on your NextSeq 1000/2000 instrument. Refer to the installation guide for instructions on identifying which OS image version is installed on your instrument.
Instructions
- Download the installation guide below to install TuxCare CentOS 7 security patches on your NextSeq 1000/2000 instrument.
- Download the patch files for the OS image version installed on your instrument. Refer to the installation guide for descriptions of the patch files and instructions on identifying the installed OS image version.
- Follow the instructions from the guide to install the patches.
NovaSeq X
Coming Soon—Q1 2025
If you are unable to install operating system security patches per your internal security policy, the following are recommended alternatives:
- Place the system on an isolated network
- Utilize an air-gapped network attached storage (NAS) appliance that allows data to sync to the network.
- Apply the appropriate permission-based controls to user accounts.
- Make sure that the instrument control computer is only used for the operation of the Illumina sequencing system, and is not used as a general purpose computer. For more information, refer to User Behavior.
- Follow the instructions provided as part of Cybersecurity Guidance.
A MyIllumina account is required to download the listed files. You may be prompted to log in to your MyIllumina account and provide an instrument serial number OR a customer number when selecting a file from the list.
For MyIllumina login support, contact Customer Care.